Cell Phones and Cancer Risk (via National Cancer Institute)

A fact sheet that outlines the available evidence regarding use of cellular/mobile telephones and cancer risk.

There are three main reasons why people are concerned that cell phones (also known as “mobile” or “wireless” telephones) might have the potential to cause certain types of cancer or other health problems:

  • Cell phones emit radiofrequency energy (radio waves), a form of non-ionizing radiation, from their antennas. Tissues nearest to the antenna can absorb this energy.
  • The number of cell phone users has increased rapidly. As of December 2014, there were more than 327.5 million cell phone subscribers in the United States, according to the Cellular Telecommunications and Internet Association. This is a nearly threefold increase from the 110 million users in 2000. Globally, the number of subscriptions is estimated by the International Telecommunications Union to be 5 billion.
  • Over time, the number of cell phone calls per day, the length of each call, and the amount of time people use cell phones have increased. However, improvements in cell phone technology have resulted in devices that have lower power outputs than earlier models.
What is radiofrequency energy and how does it affect the body?

Radiofrequency energy is a form of electromagnetic radiation. Electromagnetic radiation can be categorized into two types: ionizing (e.g., x-rays, radon, and cosmic rays) and non-ionizing (e.g., radiofrequency and extremely low frequency, or power frequency). Electromagnetic radiation is defined according to its wavelength and frequency, which is the number of cycles of a wave that pass a reference point per second. Electromagnetic frequencies are described in units called hertz (Hz).

The energy of electromagnetic radiation is determined by its frequency; ionizing radiationis high frequency, and therefore high energy, whereas non-ionizing radiation is low frequency, and therefore low energy. The NCI fact sheet Electromagnetic Fields and Cancer lists sources of radiofrequency energy. More information about ionizing radiation can be found on the Radiation page.

The frequency of radiofrequency electromagnetic radiation ranges from 30 kilohertz (30 kHz, or 30,000 Hz) to 300 gigahertz (300 GHz, or 300 billion Hz).  Electromagnetic fields in the radiofrequency range are used for telecommunications applications, including cell phones, televisions, and radio transmissions. The human body absorbs energy from devices that emit radiofrequency electromagnetic radiation. The dose of the absorbed energy is estimated using a measure called the specific absorption rate (SAR), which is expressed in watts per kilogram of body weight.

Exposure to ionizing radiation, such as from x-rays, is known to increase the risk of cancer. However, although many studies have examined the potential health effects of non-ionizing radiation from radar, microwave ovens, cell phones, and other sources, there is currently no consistent evidence that non-ionizing radiation increases cancer risk (1).

The only consistently recognized biological effect of radiofrequency energy is heating. The ability of microwave ovens to heat food is one example of this effect of radiofrequency energy. Radiofrequency exposure from cell phone use does cause heating to the area of the body where a cell phone or other device is held (ear, head, etc.). However, it is not sufficient to measurably increase body temperature, and there are no other clearly established effects on the body from radiofrequency energy.

It has been suggested that radiofrequency energy might affect glucose metabolism, but two small studies that examined brain glucose metabolism after use of a cell phone showed inconsistent results. Whereas one study showed increased glucose metabolism in the region of the brain close to the antenna compared with tissues on the opposite side of the brain (2), the other study (3) found reduced glucose metabolism on the side of the brain where the phone was used.

Another study investigated whether exposure to the radiofrequency energy from cell phones affects the flow of blood in the brain and found no evidence of such an effect (4).

The authors of these studies noted that the results are preliminary and that possible health outcomes from changes in glucose metabolism are still unknown. Such inconsistent findings are not uncommon in experimental studies of the biological effects of radiofrequency electromagnetic radiation (5). Some contributing factors include assumptions used to estimate doses, failure to consider temperature effects, and lack of blinding of investigators to exposure status.

How is radiofrequency energy exposure measured in epidemiologic studies?

Epidemiologic studies use information from several sources, including questionnaires and data from cell phone service providers. Direct measurements are not yet possible outside of a laboratory setting. Estimates take into account the following:

  • How “regularly” study participants use cell phones (the number of calls per week or month)
  • The age and the year when study participants first used a cell phone and the age and the year of last use (allows calculation of the duration of use and time since the start of use)
  • The average number of cell phone calls per day, week, or month (frequency)
  • The average length of a typical cell phone call
  • The total hours of lifetime use, calculated from the length of typical call times, the frequency of use, and the duration of use
What has research shown about the possible cancer-causing effects of radiofrequency energy?

Radiofrequency energy, unlike ionizing radiation, does not cause DNA damage that can lead to cancer. Its only consistently observed biological effect in humans is tissue heating. In animal studies, it has not been found to cause cancer or to enhance the cancer-causing effects of known chemical carcinogens (68). The National Institute of Environmental Health Sciences (NIEHS), which is part of the National Institutes of Health (NIH), is carrying out a large-scale study in rodents of exposure to radiofrequency energy (the type used in cell phones). This investigation is being conducted in highly specialized labs that can specify and control sources of radiation and measure their effects. Preliminary results from this study were released in May 2016.

Researchers have carried out several types of epidemiologic studies to investigate the possibility of a relationship between cell phone use and the risk of malignant (cancerous) brain tumors, such as gliomas, as well as benign (noncancerous) tumors, such as acousticneuromas (tumors in the cells of the nerve responsible for hearing), most meningiomas(tumors in the meninges, membranes that cover and protect the brain and spinal cord), and parotid gland tumors (tumors in the salivary glands) (9).

In one type of study, called a case-control study, cell phone use is compared between people with these types of tumors and people without them. In another type of study, called a cohort study, a large group of people who do not have cancer at study entry is followed over time and the rate of these tumors in people who did and didn’t use cell phones is compared. Cancer incidence data can also be analyzed over time to see if the rates of cancer changed in large populations during the time that cell phone use increased dramatically. These studies have not shown clear evidence of a relationship between cell phone use and cancer. However, researchers have reported some statistically significantassociations for certain subgroups of people.

Three large epidemiologic studies have examined the possible association between cell phone use and cancer: Interphone, a case-control study; the Danish Study, a cohort study; and the Million Women Study, another cohort study.

  • InterphoneHow the study was done: This is the largest health-related case-control study of cell phone use and the risk of head and neck tumors. It was conducted by a consortium of researchers from 13 countries. The data came from questionnaires that were completed by study participants.

    What the study showed: Most published analyses from this study have shown no statistically significant increases in brain or central nervous system cancers related to higher amounts of cell phone use. One analysis showed a statistically significant, although modest, increase in the risk of glioma among the small proportion of study participants who spent the most total time on cell phone calls. However, the researchers considered this finding inconclusive because they felt that the amount of use reported by some respondents was unlikely and because the participants who reported lower levels of use appeared to have a slightly reduced risk of brain cancer compared with people who did not use cell phones regularly (5,10,11). Another recent analysis from this study found no relationship between brain tumor locations and regions of the brain that were exposed to the highest level of radiofrequency energy from cell phones (12).

Source: National Cancer Institute

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